期刊
NATURE GENETICS
卷 42, 期 5, 页码 373-375出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.566
关键词
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资金
- Biotechnology and Biological Sciences Research Council [BB/F020481/1] Funding Source: researchfish
- Kidney Research UK [RP24/2/2006] Funding Source: researchfish
- Medical Research Council [G0700931, G0600705, MC_U106179471, MC_U106188470, G0801056, G0400546B, G0600420, G0400874, G0400546, G9521010, G0701863, G0601966, G0801056B, MC_UP_A100_1003] Funding Source: researchfish
- National Institute for Health Research [PHCS/C4/4/016, NF-SI-0507-10315] Funding Source: researchfish
- BBSRC [BB/F020481/1] Funding Source: UKRI
- MRC [G0400546, G0601966, G0801056, G9521010, MC_UP_A100_1003, G0600705, G0701863, G0400874, G0700931, MC_U106188470] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F020481/1] Funding Source: Medline
- Intramural NIH HHS [Z01 AG000675-02] Funding Source: Medline
- Medical Research Council [G0400874, G0600705, G0600420, G0701863, G9521010, G0601966, G0801056, MC_UP_A100_1003, G0700931, G0400546, MC_U106179471, MC_U106188470] Funding Source: Medline
- Wellcome Trust [091746] Funding Source: Medline
- Department of Health [PHCS/C4/4/016] Funding Source: Medline
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
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