期刊
NATURE GENETICS
卷 42, 期 9, 页码 739-741出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.639
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资金
- Medical Research Council [G19/9, G0600718B, MC_U190071468] Funding Source: researchfish
- MRC [MC_U190071468, G19/9] Funding Source: UKRI
- Medical Research Council [MC_U190071468, G19/9] Funding Source: Medline
- Wellcome Trust [079828, 084818, 076438] Funding Source: Medline
We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.
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