期刊
NATURE GENETICS
卷 42, 期 8, 页码 661-664出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.626
关键词
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资金
- National Cancer Institute (NCI), US National Institutes of Health (NIH) [CA122663, CA104682, CA45614, CA89745]
- American Cancer Society [IRG-07-06401]
- Agency for Science and Technology and Research of Singapore (A*STAR)
- NCI [R01 CA91253, R01 CA118444, CA62006]
- Swedish Cancer Society
- Swedish Research Council
- Danish Medical Research Council
- Information Management Services, Inc.
- NIH (NCI)
- US Public Health Service (PHS) [N01-PC-65064, N01-PC-67008, N01-PC-67009, N01-PC-67010, N02-PC-71105]
- National Health and Medical Research Council of Australia
- Cancer Council NSW
- University of Sydney Medical Foundation
- Canadian Cancer Society
- Canadian Institutes of Health Research
- German Jose Carreras Leukemia Foundation [DJCLS_R04/08, R07/26f]
- EC [QLK4-CT-2000-00422]
- Federal Office for Radiation Protection (Germany) [StSch4261, StSch4420]
- Spanish Ministry of Health [06/02/0073]
- FIS [08-1555]
- Marato TV3 (Spain) [051210]
- La Fondation de France [1999 0084 71]
- Compagnia di San Paolo di Torino
- Health Research Board, Ireland
- Ministry of Health of the Czech Republic [MZ0 MOU 2005]
To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).
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