期刊
NATURE GENETICS
卷 42, 期 8, 页码 692-U71出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.622
关键词
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资金
- US National Heart, Lung, and Blood Institute (NHLBI) [HL064310, HL044682, HL087698, HL58625]
- National Institutes of Health [R01HL089650-02]
- European Community [FP7/2007-2013, HEALTH-F2-2008-200647, HEALTH-F4-2007-201413]
- Swedish Research Council [12660]
- F. Lundberg
- US National Institute of Neurological Disorders and Stroke [NS034395]
- American Heart Association
- University of Kuopio
- Netherlands Heart Foundation [2009T001, 2005T014]
- Health Research Council of New Zealand
- UK Medical Research Council
- British Heart Foundation
- Instituto Carlos III, Spain [RECAVA RD06/0014/0004, RD06/0014/0039, 06/0014/0016]
- Novartis Foundation for Cardiovascular Excellence
- Danish Research Council
- Danish Diabetes Association
- Danish Centre for Health Technology Assessment
- Novo Nordisk
- Research Foundation of Copenhagen County
- Danish Ministry of Internal Affairs and Health
- Danish Heart Foundation
- Danish Pharmaceutical Association
- Augustinus Foundation
- Ib Henriksen Foundation
- Becket Foundation
- Velux foundation
- MRC [G0501184] Funding Source: UKRI
- Medical Research Council [G0501184, G9817803B] Funding Source: researchfish
We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.
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