期刊
NATURE GENETICS
卷 42, 期 11, 页码 1005-U132出版社
NATURE PORTFOLIO
DOI: 10.1038/ng.690
关键词
-
资金
- High-Tech Research and Development Program of China [2007AA02Z161]
- Natural Science Foundation of China [30530670, 30771196, 30771942, 30800990, 81072461, 81071285, 30972727, 30800610, 81000691]
- US National Institutes of Health (NIH) [R01AR050266, R01AR42742, R01AR054966, R01AR050511]
- German Ministry of Education
- National Genome Research Network [BMFT 01GS 0171, BMBF NUW-S23T10]
- National Psoriasis Foundation of the US
- Agency for Science, Technology and Research of Singapore
We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 x 10(-8)) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 x 10(-21)) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 x 10(-3) and P = 7.9 x 10(-3), respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 x 10(-3) and P = 1.5 x 10(-3), respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据