期刊
NATURE GENETICS
卷 42, 期 8, 页码 655-657出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.631
关键词
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资金
- Canadian Institutes for Health Research [MOP 74621]
- Ontario Research Fund [RE01-061]
- Canadian Primary Biliary Cirrhosis Society
- Canadian Foundation for Innovation
- Ben and Hilda Katz Charitable Foundation
- US National Institutes of Health [K23 DK68290, RO3 DK78527, RO1 DK80670]
- American Gastroenterological Association
- A.J. and Sigismunda Palumbo Charitable Trust
- Canada Research Chair
We genotyped individuals with primary biliary cirrhosis and unaffected controls for suggestive risk loci (genome-wide association P < 1 x 10(-4)) identified in a previous genome-wide association study. Combined analysis of the genome-wide association and replication datasets identified IRF5-TNPO3 (combined P = 8.66 x 10(-13)), 17q12-21 (combined P = 3.50 x 10(-13)) and MMEL1 (combined P = 3.15 x 10(-8)) as new primary biliary cirrhosis susceptibility loci. Fine-mapping studies showed that a single variant accounts for the IRF5-TNPO3 association. As these loci are implicated in other autoimmune conditions, these findings confirm genetic overlap among such diseases.
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