期刊
NATURE GENETICS
卷 41, 期 6, 页码 666-676出版社
NATURE PORTFOLIO
DOI: 10.1038/ng.361
关键词
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资金
- MRC [G0800759, MC_U106188470, G0801056, G0501942, MC_U137686857, MC_U105630924, G0000934, G0400874, G0701863, G0600329, G0800675, MC_qA137934, G9521010] Funding Source: UKRI
- Cancer Research UK [10589] Funding Source: researchfish
- Chief Scientist Office [CZB/4/540] Funding Source: researchfish
- Medical Research Council [G0800675, MC_U105630924, G0800759, G0801056, MC_qA137934, G0400874, G9521010, MC_U106188470, G0000934, G0801056B, G0401527, G0501942, G0701863, G0600329, MC_U137686857] Funding Source: researchfish
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
- British Heart Foundation [PG02/128, SP/04/002, FS/05/061/19501] Funding Source: Medline
- Cancer Research UK [10589] Funding Source: Medline
- Intramural NIH HHS [Z01 HG000024] Funding Source: Medline
- Medical Research Council [G0800759, MC_QA137934, G0801056, G0501942, MC_U137686857, G0000934, G0400874, G0701863, G9521010, 85374, MC_U106188470, G0600329, MC_U105630924, G9521010D, G0401527, G0800675] Funding Source: Medline
- NCRR NIH HHS [U54RR020278, U54 RR020278] Funding Source: Medline
- NHGRI NIH HHS [1Z01HG000024] Funding Source: Medline
- NHLBI NIH HHS [R01HL087676, R01HL087679, R01 HL056931-02, R01 HL087679, R01 HL087676, K23HL80025, K23 HL083102, K23HL083102, K23 HL080025-04, R01 HL056931-03, K23 HL080025, R01HL056931, R01 HL056931-04] Funding Source: Medline
- NIA NIH HHS [N01AG-821336, N01-AG-1-2109, N01AG-916413] Funding Source: Medline
- NICHD NIH HHS [N01-HD-1-3107] Funding Source: Medline
- NIDA NIH HHS [U54DA021519, U54 DA021519] Funding Source: Medline
- NIDDK NIH HHS [U01DK062418, DK062370, R01 DK072193, U01 DK062370, R01 DK062370, U01 DK062418, R56 DK062370, DK072193] Funding Source: Medline
- NIEHS NIH HHS [P30ES007033, P30 ES007033] Funding Source: Medline
- NIMHD NIH HHS [263MD916413, 263MD821336] Funding Source: Medline
- NIMH NIH HHS [RL1 MH083268, RL1MH083268] Funding Source: Medline
- PHS HHS [263-MA-410953] Funding Source: Medline
- Wellcome Trust [070191/Z/03/Z, 090532, 077016/Z/05/Z, 076113, 061858, 077016, 079557, WT088885/Z/09/Z, 077011, 089061, 079895, 088885, 076113/B/04/Z, 068545/Z/02] Funding Source: Medline
- Chief Scientist Office [CZB/4/540] Funding Source: Medline
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N <= 71,225 European ancestry, N <= 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10(-24)), CYP1A2 (P = 1 x 10(-23)), FGF5 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF652 (P = 5 x 10(-9)) and PLCD3 (P = 1 x 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.
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