期刊
NATURE GENETICS
卷 41, 期 8, 页码 899-U54出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.407
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资金
- Cancer Research UK [C1298/A8362] Funding Source: Medline
- Medical Research Council [G0000934] Funding Source: Medline
- NCI NIH HHS [5R01 CA070917, 5R01 CA119215, R01 CA119215, R01 CA070917, T32 CA096520] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- Medical Research Council [G0000934] Funding Source: researchfish
- MRC [G0000934] Funding Source: UKRI
To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.
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