期刊
NATURE GENETICS
卷 42, 期 1, 页码 53-U71出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.496
关键词
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资金
- Medical Research Council and the Biotechnology and Biological Sciences Research Council, UK
- BBSRC [BB/E017460/1, BBS/E/B/0000M723, BBS/E/B/0000C151] Funding Source: UKRI
- MRC [G0800036] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E017460/1, BBS/E/B/0000M723, BBS/E/B/0000C151] Funding Source: researchfish
- Medical Research Council [G0800036] Funding Source: researchfish
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK046865] Funding Source: NIH RePORTER
The discovery of interchromosomal interactions in higher eukaryotes points to a functional interplay between genome architecture and gene expression, challenging the view of transcription as a one-dimensional process. However, the extent of interchromosomal interactions and the underlying mechanisms are unknown. Here we present the first genome-wide analysis of transcriptional interactions using the mouse globin genes in erythroid tissues. Our results show that the active globin genes associate with hundreds of other transcribed genes, revealing extensive and preferential intra- and interchromosomal transcription interactomes. We show that the transcription factor Klf1 mediates preferential co-associations of Klf1-regulated genes at a limited number of specialized transcription factories. Our results establish a new gene expression paradigm, implying that active co-regulated genes and their regulatory factors cooperate to create specialized nuclear hot spots optimized for efficient and coordinated transcriptional control.
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