期刊
NATURE GENETICS
卷 41, 期 8, 页码 882-884出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.403
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资金
- National Institutes of Health [R01 CA129435, R01 CA109147]
- Mayer Foundation
- H. L. Snyder Medical Foundation
- Dana-Farber/Harvard Cancer Center Prostate Cancer SPORE [5P50CA90381]
- Prostate Cancer Foundation
- Whittier Foundation
- American Cancer Society Institutional Research [IRG -58-007-48]
- American Society of Clinical Oncology
An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that the region harboring this variant is a transcriptional enhancer, that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2) and that the risk region physically interacts with the MYC protooncogene. These data provide strong support for a biological mechanism underlying this non-protein-coding risk variant.
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