期刊
NATURE GENETICS
卷 41, 期 5, 页码 521-523出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.349
关键词
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资金
- Wellcome Trus
- EMBO fellowship
- Kay Kendall Leukaemia Fund fellowship
- Robert A. and Renee E. Belfer Foundation for Innovative Cancer Science
- Leukemia and Lymphoma Society
Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.
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