期刊
NATURE GENETICS
卷 41, 期 4, 页码 393-395出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.363
关键词
-
资金
- US National Institutes of Health [U54HG003042, R01GM071852]
- [R01GM078598]
- [R01MH084676]
- [U54LM008748]
- [R01GM60987]
Eukaryotic DNA replication is highly stratified, with different genomic regions shown to replicate at characteristic times during S phase. Here we observe that mutation rate, as reflected in recent evolutionary divergence and human nucleotide diversity, is markedly increased in later-replicating regions of the human genome. All classes of substitutions are affected, suggesting a generalized mechanism involving replication time-dependent DNA damage. This correlation between mutation rate and regionally stratified replication timing may have substantial evolutionary implications.
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