期刊
NATURE GENETICS
卷 41, 期 2, 页码 157-159出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.301
关键词
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资金
- Agence Nationale de la Recherche,
- Conseil Regional Nord-Pas de Calais/Fonds europeen de developpement economique et regional,''
- Genome Quebec/Genome Canada
- Medical Research Council
- German Research Council [KFO152]
- European Commission [QLG1-CT-2000-01643]
- Biocenter, University of Oulu
- DNA [NFBC1986]
- Medical Research Council [G0600331] Funding Source: researchfish
- MRC [G0600331] Funding Source: UKRI
We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).
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