期刊
NATURE GENETICS
卷 41, 期 5, 页码 596-601出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.347
关键词
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资金
- German Ministry of Education and Research (BMBF) through the Clinical Research Group for Allergy at Charite Berlin
- National Genome Research Network (NGFN)
- PopGen biobank and infrastructure support through the DFG cluster of excellence Inflammation at Interfaces'
- EMBO long-term fellowship [522-2006]
- Marie Curie EIF fellowship [039868]
- German Research Council [DFG NO454/1-4, NO454/2-4, NO454/5-2, SFB704 TPA4]
- BONFOR grants of the University of Bonn
- University Hospital Rechts der Isar [KKF-07/04, KKF-27/05]
- Technische Universitat Munchen
- Wilhelm-Vaillant-Stiftung and a Heisenberg fellowship [DFG WE 2678/4-1]
- German Research Council
- [VZFNM00064203]
We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (P-combined = 7.6 x 10(-10)). Approximately 13% of individuals of European origin are homozygous for rs7927894[A], and their risk of developing atopic dermatitis is 1.47 times that of noncarriers.
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