期刊
NATURE GENETICS
卷 42, 期 1, 页码 24-26出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.506
关键词
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资金
- Deutsche Forschungsgemeinschaft [FOR 423, MA 2546/3-1, KR 1912/7-1, NO 246/6-1, WI 1555/5-1]
- Heinz Nixdorf Foundation, Germany
- Ministry of Science, Economy and Transport of Schleswig-Holstein, Germany
- German Federal Ministry of Education and Research
- German Federal Ministry of Education and Research (BMBF)
- European Commission [QLG1-CT-2000-01019]
- University of Ferrara, Italy [FAR-2008]
- Conselho Nacional de Pesquisa (CNPq), Brasil
- Ministry of Higher Education, Syrian Arab Republic
We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56).
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