期刊
NATURE GENETICS
卷 41, 期 6, 页码 648-650出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.386
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资金
- Intramural NIH HHS Funding Source: Medline
- NCRR NIH HHS [M01 RR016500-02, M01 RR 16500] Funding Source: Medline
- NHLBI NIH HHS [N01 HC025195, N01 HC055018, N01-HC-25195, N01 HC055022, U01 HL72515, N01 HC055016, N02-HL-6-4278, N01-HC-55018, N01 HC055015, N01 HC055019, N02 HL64278, U01 HL072515, N01-HC-55020, N01-HC-55016, N01-HC-55015, N01 HC055020, N01-HC-55022, N01-HC-55019, N01 HC055021, U01 HL072515-06, N01-HC-55021] Funding Source: Medline
- NIAMS NIH HHS [R01 AR041398, R01 AR041398-15] Funding Source: Medline
- NIA NIH HHS [R21 AG032598, N01-AG-12100, N01 AG012100, U19 AG023122, N.1-AG-1-2111, N.1-AG-1-1, R21AG032598, R01 AR/AG 41398, N01-AG-5-0002, U19 AG023122-05, R21 AG032598-02] Funding Source: Medline
- NIDDK NIH HHS [P30 DK072488-02, P30 DK072488] Funding Source: Medline
- NIMHD NIH HHS [263 MD821336, 263 MD9164 13, 263 MD 821336, 263 MD 9164] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 x 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 x 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.
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