期刊
NATURE GENETICS
卷 41, 期 4, 页码 407-414出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.362
关键词
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资金
- National Heart, Lung, and Blood Institute [N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022, R01HL087641, R01HL59367, R01HL086694]
- National Human Genome Research Institute [U01HG004402]
- National Institutes of Health [HHSN268200625226C, UL1RR025005]
- NHLBI [HL86694, HL054512]
- Donald W. Reynolds Cardiovascular Clinical Research Center at Johns Hopkins University
- German Research Foundation Fellowship
- German Federal Ministry of Education and Research (BMBF)
- German National Genome Research Network (NGFN)
- German National Competence network on atrial fibrillation (AFNET)
- Bioinformatics for the Functional Analysis of Mammalian Genomes [NGFN 01GS0499, 01GS0838, AF-Net01GI0204/N]
- Fondation Leducq
- State of Bavaria
- National Institute on Aging [NO1-AG-1-2109]
- National Institute on Aging to the University of Michigan [263-MA-410953]
- National Human Genome Research Institute
- National Heart, Lung, and Blood Institute
- Ministry of Health of the Autonomous Province of Bolzano
- South Tyrolean Sparkasse Foundation
- Heinz Nixdorf Foundation
- [NGFN 01GR0803]
- [01EZ0874]
- [NGFN 01GI0204]
- [NGFN 01GR0103]
The QT interval, a measure of cardiac repolarization, predisposes to ventricular arrhythmias and sudden cardiac death ( SCD) when prolonged or shortened. A common variant in NOS1AP is known to influence repolarization. We analyze genome-wide data from five population-based cohorts (ARIC, KORA, SardiNIA, GenNOVA and HNR) with a total of 15,842 individuals of European ancestry, to confirm the NOS1AP association and identify nine additional loci at P < 5 x 10(-8). Four loci map near the monogenic long-QT syndrome genes KCNQ1, KCNH2, SCN5A and KCNJ2. Two other loci include ATP1B1 and PLN, genes with established electrophysiological function, whereas three map to RNF207, near LITAF and within NDRG4-GINS3-SETD6-CNOT1, respectively, all of which have not previously been implicated in cardiac electrophysiology. These results, together with an accompanying paper from the QTGEN consortium, identify new candidate genes for ventricular arrhythmias and SCD.
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