期刊
NATURE GENETICS
卷 40, 期 8, 页码 955-962出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.175
关键词
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资金
- MRC [G0600329, G0000934] Funding Source: UKRI
- Medical Research Council [G0800759, G0600329, G0000934] Funding Source: Medline
- NIAID NIH HHS [R01 AI062773-02, R01 AI062773, AI06277] Funding Source: Medline
- NIDDK NIH HHS [U01 DK062422, U01 DK062429, P30 DK040561-13, U01 DK062422-07, U01 DK062423-06, P30 DK063491, P30 DK063491-05, U01 DK062420-01, DK62420, DK62429, R01 DK064869, U01 DK062431, U01 DK062431-06, U01 DK062420, DK62432, U01 DK062413-06, U01 DK062420-06, U01 DK062423, DK62423, U01 DK062420-04, U01 DK062429-07, P30 DK063491-049004, DK62413, U01 DK062420-03, P30 DK063491-019004, P30 DK063491-029004, U01 DK062432, R01 DK064869-04, U01 DK062413, U01 DK062420-05, P30 DK040561, DK064869, DK62431, P30 DK063491-039004, DK62422, U01 DK062420-02] Funding Source: Medline
- Wellcome Trust [068545/Z/02] Funding Source: Medline
- Chief Scientist Office [CZB/4/540] Funding Source: Medline
- Chief Scientist Office [CZB/4/540] Funding Source: researchfish
- Medical Research Council [G0000934, G0600329] Funding Source: researchfish
Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease ( a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.
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