期刊
NATURE GENETICS
卷 41, 期 1, 页码 66-70出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.303
关键词
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资金
- US National Human Genome Research Institutes (NHGRI)
- US National Institutes of Health (NIH)
- Wellcome Career Development Award in the Biomedical Sciences
- NIH [U01 HG004168]
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U01HG004168, ZIAHG200330] Funding Source: NIH RePORTER
Comparisons of chromosome X and the autosomes can illuminate differences in the histories of males and females as well as shed light on the forces of natural selection. We compared the patterns of variation in these parts of the genome using two datasets that we assembled for this study that are both genomic in scale. Three independent analyses show that around the time of the dispersal of modern humans out of Africa, chromosome X experienced much more genetic drift than is expected from the pattern on the autosomes. This is not predicted by known episodes of demographic history, and we found no similar patterns associated with the dispersals into East Asia and Europe. We conclude that a sex-biased process that reduced the female effective population size, or an episode of natural selection unusually affecting chromosome X, was associated with the founding of non-African populations.
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