期刊
NATURE GENETICS
卷 40, 期 10, 页码 1185-1192出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.232
关键词
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资金
- AGENCY FOR HEALTHCARE RESEARCH AND QUALITY [R01HS008365] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [ZIABC010022, ZIABC010297] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR001346, M01RR000827, M01RR007122, M01RR000425, M01RR000080] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL062985] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [ZIADK069094, U01DK070657, ZIADK069000, R01DK059997, K01DK067207, R01DK072348, R01DK067528, U01DK057304, T32DK007024, U01DK057292] Funding Source: NIH RePORTER
- AHRQ HHS [R01 HS008365, HS08365] Funding Source: Medline
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [N01-CO-12400, N01CO12400] Funding Source: Medline
- NCRR NIH HHS [M01 RR007122, M01-RR-000080, M01 RR000827, M01-RR-00827-29, M01 RR001346, M01-RR-01346, M01-RR-00425, M01-RR-07122, M01 RR000080, M01 RR000425] Funding Source: Medline
- NHLBI NIH HHS [R01 HL062985, HL62985] Funding Source: Medline
- NIDDK NIH HHS [U01 DK070657-02, U01DK070657, U01 DK070657, DK07024, U01DK57304, R01 DK059997, U01 DK070657-03, U01 DK070657-01, U01 DK057292, U01 DK057304, K01 DK067207, R01 DK067528-05, R01 DK072348-04, R01 DK067528, R01 DK072348, K01DK067207, U01DK57292, R01 DK059997-04] Funding Source: Medline
As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% CI = 0.39-0.63) compared to African ancestry. Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans.
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