期刊
NATURE GENETICS
卷 40, 期 9, 页码 1053-1055出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.201
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资金
- MRC
- Wellcome Trust
- Science Foundation Ireland
- Health Research Board (Ireland)
- National Genomic Network of the 'Bundesministerium fur Bildung und Forschung' (BMBF)
- Alfried Krupp von Bohlen und Halbach-Stiftung
- GlaxoSmithKline.
- Medical Research Council [G9810900] Funding Source: researchfish
- MRC [G9810900] Funding Source: UKRI
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P < 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).
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