期刊
NATURE GENETICS
卷 40, 期 2, 页码 158-160出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2007.55
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资金
- NHGRI NIH HHS [HG003988, R01 HG003988-02, R01 HG003988] Funding Source: Medline
- NHLBI NIH HHS [U01 HL066681, HL066681] Funding Source: Medline
Extended perfect human-rodent sequence identity of at least 200 base pairs (ultraconservation) is potentially indicative of evolutionary or functional uniqueness. We used a transgenic mouse assay to compare the embryonic enhancer activity of 231 noncoding ultraconserved human genome regions with that of 206 extremely conserved regions lacking ultraconservation. Developmental enhancers were equally prevalent in both populations, suggesting instead that ultraconservation identifies a small, functionally indistinct subset of similarly constrained cis-regulatory elements.
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