期刊
NATURE GENETICS
卷 40, 期 6, 页码 710-712出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.145
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资金
- Medical Research Council [MC_U105260799, G0800759, MC_QA137934, G0800383, G0600329, G0802320, G0400874, G0000934] Funding Source: Medline
- Wellcome Trust [090532, 076113, 089120, 077011] Funding Source: Medline
- Chief Scientist Office [CZB/4/540] Funding Source: Medline
- MRC [MC_U105260799, G0800383, G0000934, G0400874, G0600329, MC_qA137934] Funding Source: UKRI
- Chief Scientist Office [CZB/4/540] Funding Source: researchfish
- Medical Research Council [G0600329, MC_qA137934, G0400874, G0800383, G0000934, MC_U105260799] Funding Source: researchfish
We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.
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