期刊
NATURE GENETICS
卷 40, 期 10, 页码 1156-1159出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.218
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资金
- Arthritis Research Campaign [17552]
- National Health Service (NHS) Research and Development
- Guy's and St Thomas' and Lewisham NHS Trusts
- Medical Research Council [G0000934]
- Wellcome Trust [068545/Z/02]
- European Community's Sixth Framework Programme Autocure
- MRC [G0600329, G0000934] Funding Source: UKRI
- Chief Scientist Office [CZB/4/540] Funding Source: researchfish
- Medical Research Council [G0600329, G0000934] Funding Source: researchfish
The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.
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