期刊
NATURE GENETICS
卷 40, 期 12, 页码 1399-1401出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.249
关键词
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资金
- Juvenile Diabetes Research Foundation International
- Wellcome Trust
- National Institute for Health Research Cambridge Biomedical Centre
- Wellcome Trust Strategic Award [079895]
- Wellcome Trust [076113]
- MRC [G0000934] Funding Source: UKRI
- Medical Research Council [G0000934] Funding Source: researchfish
We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (IL2-IL21, P = 1.9 x 10(-8)) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci in chromosome regions 6q15 (BACH2, P = 4.7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8)).
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