期刊
NATURE GENETICS
卷 40, 期 2, 页码 134-135出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng0208-134
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资金
- NIA NIH HHS [R01 AG019787] Funding Source: Medline
Rapid changes in mitochondrial DNA allele frequency between generations have been explained by an 'mtDNA bottleneck' in the germ line, and it has recently been proposed that mtDNA aggregates, or nucleoids, drive such a bottleneck. Now, a new study finds a sharp reduction in mtDNA content in the germ line and suggests that such reduction alone may account for the bottleneck effect.
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