期刊
NATURE CHEMISTRY
卷 10, 期 10, 页码 1048-1055出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41557-018-0087-7
关键词
-
资金
- National Science Foundation (NSF) via the CCI Center for Selective C-H Functionalization [CHE-1700982]
- NSF MRI-R2 grant [CHE-0958205]
- NSF [CHE 1531620, CHE 1626172]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [F32GM122218] Funding Source: NIH RePORTER
- Division Of Chemistry [1531620] Funding Source: National Science Foundation
C-H functionalization represents a promising approach for the synthesis of complex molecules. Instead of relying on modifying the functional groups present in a molecule, the synthetic sequence is achieved by carrying out selective reactions on the C-H bonds, which traditionally would have been considered to be the unreactive components of a molecule. A major challenge is to design catalysts to control both the site- and stereoselectivity of the C-H functionalization. We have been developing dirhodium catalysts with different selectivity profiles in C-H functionalization reactions with donor/acceptor carbenes as reactive intermediates. Here we describe a new dirhodium catalyst capable of the functionalization of non-activated primary C-H bonds with high levels of site selectivity and enantioselectivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据