期刊
NATURE CHEMISTRY
卷 6, 期 7, 页码 624-629出版社
NATURE PORTFOLIO
DOI: 10.1038/NCHEM.1938
关键词
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资金
- Air Force Office of Scientific Research Discovery Program [392 AF FA9550-10-1-0255]
- National Science Foundation [CHE-1300313]
- US Army Research Laboratory
- US Army Research Office [W911NF-07-1-0409]
- Department of Defense (Office of the Assistant Secretary of Defense for Research and Engineering) through an NSSEFF fellowship
- Energy Frontier Research Center funded by the US Department of Energy, Office of Science, Office of Basic Energy Sciences [DOE ANL 9F-31921J]
- University ofWashington
- University ofWashington Royalty Research Fund
- US Army Research Office Young Investigator Program [W911NF-11-1-0289]
- Career Award at the Scientific Interface from the BurroughsWellcome Fund
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1300313] Funding Source: National Science Foundation
Biological systems rely on recyclable materials resources such as amino acids, carbohydrates and nucleic acids. When biomaterials are damaged as a result of aging or stress, tissues undergo repair by a depolymerization-repolymerization sequence of remodelling. Integration of this concept into synthetic materials systems may lead to devices with extended lifetimes. Here, we show that a metastable polymer, end-capped poly(o-phthalaldehyde), undergoes mechanically initiated depolymerization to revert the material to monomers. Trapping experiments and steered molecular dynamics simulations are consistent with a heterolytic scission mechanism. The obtained monomer was repolymerized by a chemical initiator, effectively completing a depolymerization-repolymerization cycle. By emulating remodelling of biomaterials, this model system suggests the possibility of smart materials where aging or mechanical damage triggers depolymerization, and orthogonal conditions regenerate the polymer when and where necessary.
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