期刊
NATURE CHEMISTRY
卷 6, 期 7, 页码 604-608出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEM.1949
关键词
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资金
- Medical Research Council
- European Research Council advanced grant
- Royal Society-Wolfson Research Merit Award
- Ruth L. Kirschstein NIH Postdoctoral Fellowship [F32L078236]
- MRC [G0300122] Funding Source: UKRI
- Medical Research Council [G0300122] Funding Source: researchfish
Single-molecule approaches to chemical reaction analysis can provide information that is not accessible by studying ensemble systems. Changes in the molecular structures of compounds tethered to the inner wall of a protein pore are known to affect the current carried through the pore by aqueous ions under a fixed applied potential. Here, we use this approach to study the substitution reactions of arsenic(III) compounds with thiols, stretching the limits of the protein pore technology to track the interconversion of seven reaction components in a network that comprises interconnected Walden cycles. Single-molecule pathway analysis of 'allowed' and 'forbidden' reactions reveals that sulfur-sulfur substitution occurs with stereochemical inversion at the arsenic centre. Hence, we demonstrate that the nanoreactor approach can be a valuable technique for the analysis of dynamic reaction systems of relevance to biology.
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