期刊
NATURE CHEMISTRY
卷 4, 期 6, 页码 491-497出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEM.1331
关键词
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资金
- University of Warwick
- Engineering and Physical Sciences Research Council [EP/H019146/1]
- European Science Foundation
- Birmingham Science City
- Advantage West Midlands
- European Regional Development Fund
- Wellcome Trust [055663/Z/98/Z]
- EPSRC [EP/H019146/1, EP/G004897/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/H019146/1, EP/G004897/1] Funding Source: researchfish
Segregation and templating approaches have been honed by billions of years of evolution to direct many complex biological processes. Nature uses segregation to improve biochemical control by organizing reactants into defined, well-regulated environments, and the transfer of genetic information is a primary function of templating. The ribosome, wherein messenger RNA is translated into polypeptides, combines both techniques to allow for ideal biopolymer syntheses. Herein is presented a biomimetic segregation/templating approach to synthetic radical polymerization. Polymerization of a nucleobase-containing vinyl monomer in the presence of a complementary block copolymer template of low molecular weight yields high molecular weight (M-w up to similar to 400,000 g mol(-1)), extremely low polydispersity (<= 1.08) daughter polymers. Control is attained by segregation of propagating radicals in discrete micelle cores (via cooperative assembly of dynamic template polymers). Significantly reduced bimolecular termination, combined with controlled propagation along a defined number of templates, ensures unprecedented control to afford well-defined high molecular weight polymers.
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