期刊
NATURE CHEMISTRY
卷 3, 期 8, 页码 620-627出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEM.1070
关键词
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资金
- US National Science Foundation [0832824]
- Computer and Communication Foundations Emerging Models and Technologies [0829951, 0622254]
- Semiconductor Research Corporation Focus Center on Functional Engineered Nano Architectonics
- Microsoft Corporation
- Mark Sims of Nanorex Corporation
- Benjamin M. Rosen Family Foundation
- Direct For Computer & Info Scie & Enginr
- Division of Computing and Communication Foundations [832824] Funding Source: National Science Foundation
- Division of Computing and Communication Foundations
- Direct For Computer & Info Scie & Enginr [0829951] Funding Source: National Science Foundation
From ligand-receptor binding to DNA hybridization, molecular recognition plays a central role in biology. Over the past several decades, chemists have successfully reproduced the exquisite specificity of biomolecular interactions. However, engineering multiple specific interactions in synthetic systems remains difficult. DNA retains its position as the best medium with which to create orthogonal, isoenergetic interactions, based on the complementarity of Watson-Crick binding. Here we show that DNA can be used to create diverse bonds using an entirely different principle: the geometric arrangement of blunt-end stacking interactions. We show that both binary codes and shape complementarity can serve as a basis for such stacking bonds, and explore their specificity, thermodynamics and binding rules. Orthogonal stacking bonds were used to connect five distinct DNA origami. This work, which demonstrates how a single attractive interaction can be developed to create diverse bonds, may guide strategies for molecular recognition in systems beyond DNA nanostructures.
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