期刊
NATURE CHEMISTRY
卷 3, 期 3, 页码 244-248出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEM.987
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资金
- Engineering and Physical Sciences Research Council (EPSRC)
- EPSRC [EP/H021620/1, EP/G013519/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G013519/1, EP/H021620/1] Funding Source: researchfish
Secondary electrostatic interactions between adjacent hydrogen bonds can have a significant effect on the stability of a supramolecular complex. In theory, the binding strength should be maximized if all the hydrogen-bond donors (D) are on one component and all the hydrogen-bond acceptors (A) are on the other. Here, we describe a readily accessible AAAA-DDDD quadruple hydrogen-bonding array that exhibits exceptionally strong binding for a small-molecule hydrogen-bonded complex in a range of different solvents (K-a > 3 x 10(12) M-1 in CH2Cl2, 1.5 x 10(6) M-1 in CH3CN and 3.4 x 10(5) M-1 in 10% v/v DMSO/CHCl3). The association constant in CH2Cl2 corresponds to a binding free energy (Delta G) in excess of -71 kJ mol(-1) (more than 20% of the thermodynamic stability of a carbon-carbon covalent bond), which is remarkable for a supramolecular complex held together by just four intercomponent hydrogen bonds.
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