期刊
NATURE CHEMISTRY
卷 2, 期 6, 页码 478-483出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEM.648
关键词
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资金
- Japan Science and Technology Agency
- Global COE Program Chemistry Innovation through Cooperation of Science and Engineering
- Development in a New Interdisciplinary Field Based on Nanotechnology and Materials Science Programs
- Ministry of Education, Culture, Science, Sports and Technology of Japan
Direct functionalization of alkanes by oxidation of C-H bonds to form alcohols under mild conditions is a challenge for synthetic chemistry. Most alkanes contain a large number of C-H bonds that present difficulties for selectivity, and the oxidants employed often result in overoxidation. Here we describe a divanadium-substituted phosphotungstate that catalyses the stereo- and regioselective hydroxylation of alkanes with hydrogen peroxide as the sole oxidant. Both cyclic and acyclic alkanes were oxidized to form alcohols with greater than 96% selectivity. The bulky polyoxometalate framework of the catalyst results in an unusual selectivity that can lead to the oxidation of secondary rather than the weaker tertiary C-H bonds. The catalyst also avoids wasteful decomposition of the stoichiometric oxidant, which can result in the production of hydroxyl radicals and lead to non-selective oxidation and overoxidation of the desired products.
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