期刊
NATURE CHEMISTRY
卷 1, 期 2, 页码 138-144出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEM.178
关键词
-
资金
- NSF/EPSRC
- Spanish Ministerio de Educacion y Ciencia
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0822244] Funding Source: National Science Foundation
- EPSRC [EP/D03549X/1, EP/G002576/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D03549X/1, EP/G002576/1] Funding Source: researchfish
Bicarbonate is involved in a wide range of biological processes, which include respiration, regulation of intracellular pH and fertilization. In this study we use a combination of NMR spectroscopy and ion-selective electrode techniques to show that the natural product prodigiosin, a tripyrrolic molecule produced by microorganisms such as Streptomyces and Serratia, facilitates chloride/bicarbonate exchange ( antiport) across liposomal membranes. Higher concentrations of simple synthetic molecules based on a 4,6-dihydroxyisophthalamide core are also shown to facilitate this antiport process. Although it is well known that proteins regulate Cl(-)/HCO(3)(-) exchange in cells, these results suggest that small molecules may also be able to regulate the concentration of these anions in biological systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据