期刊
NATURE CHEMICAL BIOLOGY
卷 10, 期 6, 页码 470-476出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1525
关键词
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资金
- US National Blood Foundation
- NIH
- Swiss National Science Foundation [310030_135734]
- CSL Behring AG, Bern, Switzerland
- CAPES Foundation, Ministry of Education, Brazil [BEX 9320/13-0]
- [R01AI050143]
- [P01HL107151NIH]
- [HL085607]
- [P41GM103694]
- [R24GM098791]
- [U54GM62116]
- Swiss National Science Foundation (SNF) [310030_135734] Funding Source: Swiss National Science Foundation (SNF)
Genomic approaches continue to provide unprecedented insight into the microbiome, yet host immune interactions with diverse microbiota can be difficult to study. We therefore generated a microbial microarray containing defined antigens isolated from a broad range of microbial flora to examine adaptive and innate immunity. Serological studies with this microarray show that immunoglobulins from multiple mammalian species have unique patterns of reactivity, whereas exposure of animals to distinct microbes induces specific serological recognition. Although adaptive immunity exhibited plasticity toward microbial antigens, immunological tolerance limits reactivity toward self. We discovered that several innate immune galectins show specific recognition of microbes that express self-like antigens, leading to direct killing of a broad range of Gram-negative and Gram-positive microbes. Thus, host protection against microbes seems to represent a balance between adaptive and innate immunity to defend against evolving antigenic determinants while protecting against molecular mimicry.
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