期刊
NATURE CHEMICAL BIOLOGY
卷 10, 期 11, 页码 921-923出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1625
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资金
- University of Pittsburgh-Department of Chemistry startup fund
Regio- and stereospecific incorporation of a halogen atom to an unactivated sp(3) carbon in a freestanding molecule is a challenging transformation that is currently missing in the inventory of enzyme-mediated reactions. Here we report what is to our knowledge the first example of a nonheme iron enzyme (WelO5) in the welwitindolinone biosynthetic pathway that can monochlorinate an aliphatic carbon in 12-epi-fischerindole U and 12-epi-hapalindole C, substrates that are free from peptidyl or acyl carrier protein.
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