期刊
NATURE CHEMICAL BIOLOGY
卷 10, 期 3, 页码 178-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1450
关键词
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资金
- US National Institutes of Health (NIH) [R00-GM087550]
- US National Science Foundation (NSF) BEACON Center for the Study of Evolution in Action [DBI-0939454]
- US Army Research Office [W911NF-12-1-0390]
- US National Security Science and Engineering Faculty [FA9550-10-1-01-69]
- US Defense Advanced Research Project Agency [HR-0011-12-C-0066]
- NSF [MCB-0943383]
- NIH
- NSF
- Cancer Prevention Research Institute of Texas
- Welch Foundation [F1515]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0943383] Funding Source: National Science Foundation
Bioengineering advances have made it possible to fundamentally alter the genetic codes of organisms. However, the evolutionary consequences of expanding an organism's genetic code with a noncanonical amino acid are poorly understood. Here we show that bacteriophages evolved on a host that incorporates 3-iodotyrosine at the amber stop codon acquire neutral and beneficial mutations to this new amino acid in their proteins, demonstrating that an expanded genetic code increases evolvability.
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