期刊
NATURE CHEMICAL BIOLOGY
卷 10, 期 2, 页码 93-95出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.1432
关键词
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资金
- US National Institutes of Health [GM071440, GM088599]
N-6-methyladenosine (m(6)A) is the most prevalent and reversible internal modification in mammalian messenger and noncoding RNAs. We report here that human methyltransferase-like 14 (METTL14) catalyzes m(6)A RNA methylation. Together with METTL3, the only previously known m(6)A methyltransferase, these two proteins form a stable heterodimer core complex of METTL3-METTL14 that functions in cellular m(6)A deposition on mammalian nuclear RNAs. WTAP, a mammalian splicing factor, can interact with this complex and affect this methylation.
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