相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams
Maya A. Farha et al.
ACS CHEMICAL BIOLOGY (2013)
Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening
Sarah A. Stanley et al.
ACS CHEMICAL BIOLOGY (2012)
Reshuffling of Aspergillus fumigatus Cell Wall Components Chitin and β-Glucan under the Influence of Caspofungin or Nikkomycin Z Alone or in Combination
Patricia E. B. Verwer et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I
Alex G. Therien et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Global Phenotypic Screening for Antimalarials
W. Armand Guiguemde et al.
CHEMISTRY & BIOLOGY (2012)
Towards a new tuberculosis drug: pyridomycin - nature's isoniazid
Ruben C. Hartkoorn et al.
EMBO MOLECULAR MEDICINE (2012)
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
Anna E. Grzegorzewicz et al.
NATURE CHEMICAL BIOLOGY (2012)
Phylogeny and beyond: Scientific, historical, and conceptual significance of the first tree of life
Norman R. Pace et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to β-Lactam Antibiotics
Christopher M. Tan et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Identification and in vitro Analysis of the GatD/MurT Enzyme-Complex Catalyzing Lipid II Amidation in Staphylococcus aureus
Daniela Muench et al.
PLOS PATHOGENS (2012)
Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria
Hiroshi Nikaido et al.
FEMS MICROBIOLOGY REVIEWS (2012)
Parsimonious Discovery of Synergistic Drug Combinations
Bryan Severyn et al.
ACS CHEMICAL BIOLOGY (2011)
A Chemical Genomic Analysis of Decoquinate, a Plasmodium falciparum Cytochrome b Inhibitor
Tae-gyu Nam et al.
ACS CHEMICAL BIOLOGY (2011)
Phenotypic Landscape of a Bacterial Cell
Robert J. Nichols et al.
CELL (2011)
Antagonism of Chemical Genetic Interaction Networks Resensitize MRSA to β-Lactam Antibiotics
Sang Ho Lee et al.
CHEMISTRY & BIOLOGY (2011)
Confronting the Challenges of Natural Product-Based Antifungal Discovery
Terry Roemer et al.
CHEMISTRY & BIOLOGY (2011)
Compound Prioritization Methods Increase Rates of Chemical Probe Discovery in Model Organisms
Iain M. Wallace et al.
CHEMISTRY & BIOLOGY (2011)
Challenges of Antibacterial Discovery
Lynn L. Silver
CLINICAL MICROBIOLOGY REVIEWS (2011)
Antibiotic adjuvants: multicomponent anti-infective strategies
Lindsay Kalan et al.
EXPERT REVIEWS IN MOLECULAR MEDICINE (2011)
Discovery research: the scientific challenge of finding new antibiotics
David M. Livermore
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2011)
Systematic exploration of synergistic drug pairs
Murat Cokol et al.
MOLECULAR SYSTEMS BIOLOGY (2011)
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy
Linda Ejim et al.
NATURE CHEMICAL BIOLOGY (2011)
How were new medicines discovered?
David C. Swinney et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease
Rebecca S. Shapiro et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2011)
Genomewide Screening for Novel Genetic Variations Associated with Ciprofloxacin Resistance in Bacillus anthracis
Masakuni Serizawa et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Staphylococcus aureus TargetArray: Comprehensive Differential Essential Gene Expression as a Mechanistic Tool To Profile Antibacterials
H. Howard Xu et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Antibiotic Sensitivity Profiles Determined with an Escherichia coli Gene Knockout Collection: Generating an Antibiotic Bar Code
Anne Liu et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production
Jennifer H. Moffatt et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Lipoprotein Cofactors Located in the Outer Membrane Activate Bacterial Cell Wall Polymerases
Catherine Paradis-Bleau et al.
CELL (2010)
Chemical Genomic Approaches to Study Model Microbes
Courtney A. Barker et al.
CHEMISTRY & BIOLOGY (2010)
Three Decades of beta-Lactamase Inhibitors
Sarah M. Drawz et al.
CLINICAL MICROBIOLOGY REVIEWS (2010)
The antibiotic resistome
Gerard D. Wright
EXPERT OPINION ON DRUG DISCOVERY (2010)
Essentiality of FASII pathway for Staphylococcus aureus
Wendy Balemans et al.
NATURE (2010)
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale
Anastasia Baryshnikova et al.
NATURE METHODS (2010)
An insight into the antifungal pipeline: selected new molecules and beyond
Luis Ostrosky-Zeichner et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model
Jeffrey M. Becker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The Genetic Landscape of a Cell
Michael Costanzo et al.
SCIENCE (2010)
The Bacterial Cell Envelope
Thomas J. Silhavy et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
Gene Annotation and Drug Target Discovery in Candida albicans with a Tagged Transposon Mutant Collection
Julia Oh et al.
PLOS PATHOGENS (2010)
Systematic Mapping of Genetic Interaction Networks
Scott J. Dixon et al.
ANNUAL REVIEW OF GENETICS (2009)
Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)
Roy R. Chaudhuri et al.
BMC GENOMICS (2009)
A Staphylococcus aureus Fitness Test Platform for Mechanism-Based Profiling of Antibacterial Compounds
Robert G. K. Donald et al.
CHEMISTRY & BIOLOGY (2009)
Chemical Genetic Identification of Peptidoglycan Inhibitors Potentiating Carbapenem Activity against Methicillin-Resistant Staphylococcus aureus
Joann Huber et al.
CHEMISTRY & BIOLOGY (2009)
Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America
Helen W. Boucher et al.
CLINICAL INFECTIOUS DISEASES (2009)
New triazoles and echinocandins: mode of action, in vitro activity and mechanisms of resistance
Maria Teresa Fera et al.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2009)
Quantitative phenotyping via deep barcode sequencing
Andrew M. Smith et al.
GENOME RESEARCH (2009)
Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants
Gemma C. Langridge et al.
GENOME RESEARCH (2009)
Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi
Gerald F. Bills et al.
MYCOLOGIA (2009)
Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens
Sophie Brinster et al.
NATURE (2009)
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds
Cheuk Hei Ho et al.
NATURE BIOTECHNOLOGY (2009)
Synergistic drug combinations tend to improve therapeutically relevant selectivity
Joseph Lehar et al.
NATURE BIOTECHNOLOGY (2009)
Genetic Architecture of Intrinsic Antibiotic Susceptibility
Hany S. Girgis et al.
PLOS ONE (2009)
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
Leah E. Cowen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Antibiotics for Emerging Pathogens
Michael A. Fischbach et al.
SCIENCE (2009)
Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin
Sheena D. Singh et al.
PLOS PATHOGENS (2009)
PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products
Bo Jiang et al.
CHEMISTRY & BIOLOGY (2008)
Whither antibacterial drug discovery?
Steven J. Projan
DRUG DISCOVERY TODAY (2008)
Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp K04-0144 - II. Biological activities
Atsushi Fukumoto et al.
JOURNAL OF ANTIBIOTICS (2008)
Antifungal activity against Candida albicans of nikkomycin Z in combination with caspofungin, voriconazole or amphotericin B
H. Sandovsky-Losica et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2008)
Determination of antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coli
Cindy Tamae et al.
JOURNAL OF BACTERIOLOGY (2008)
A complete collection of single-gene deletion mutants of Acinetobacter baylyi ADP1
Veronique de Berardinis et al.
MOLECULAR SYSTEMS BIOLOGY (2008)
An integrated platform of genomic assays reveals small-molecule bioactivities
Shawn Hoon et al.
NATURE CHEMICAL BIOLOGY (2008)
Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers
Zhun Yan et al.
NATURE METHODS (2008)
The Neglected Intrinsic Resistome of Bacterial Pathogens
Alicia Fajardo et al.
PLOS ONE (2008)
Defining genetic interaction
Ramamurthy Mani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
An inhibitor of FtsZ with potent and selective anti-staphylococcal activity
David J. Haydon et al.
SCIENCE (2008)
Yeast chemical genomics and drug discovery: an update
Shawn Hoon et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2008)
Evolution and pathogenesis of Staphylococcus aureus: lessons learned from genotyping and comparative genomics
Ye Feng et al.
FEMS MICROBIOLOGY REVIEWS (2008)
Reversal of resistance in microorganisms by help of non-antibiotics
Jette E. Kristiansen et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2007)
Development of genomic array footprinting for identification of conditionally essential genes in Streptococcus pneumoniae
Jetta J. E. Bijlsma et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)
Essential gene identification and drug target prioritization in Aspergillus fumigatus
Wenqi Hu et al.
PLOS PATHOGENS (2007)
Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures
Sarah E. Pierce et al.
NATURE PROTOCOLS (2007)
The antibiotic resistome: the nexus of chemical and genetic diversity
Gerard D. Wright
NATURE REVIEWS MICROBIOLOGY (2007)
Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans
Deming Xu et al.
PLOS PATHOGENS (2007)
Drugs for bad bugs: confronting the challenges of antibacterial discovery
David J. Payne et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Genes involved in intrinsic antibiotic resistance of Acinetobacter baylyi
Maria J. Gomez et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast
Ainslie B. Parsons et al.
CELL (2006)
MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter
Martin Thanbichler et al.
CELL (2006)
Marcel Faber Roundtable: Is our antibiotic pipeline unproductive because of starvation, constipation or lack of inspiration?
Richard H. Baltz
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2006)
Practical applications and feasibility of efflux pump inhibitors in the clinic - A vision for applied use
O Lomovskaya et al.
BIOCHEMICAL PHARMACOLOGY (2006)
An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants
NT Liberati et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection
Tomoya Baba et al.
MOLECULAR SYSTEMS BIOLOGY (2006)
Biochemical and genetic analysis of the yeast proteome with a movable ORF collection
DM Gelperin et al.
GENES & DEVELOPMENT (2005)
Tetracycline-inducible gene expression and gene deletion in Candida albicans
YN Park et al.
EUKARYOTIC CELL (2005)
Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli
T Wu et al.
CELL (2005)
Characterization of novel Mycobacterium tuberculosis and Mycobacterium smegmatis mutants hypersusceptible to β-lactam antibiotics
AR Flores et al.
JOURNAL OF BACTERIOLOGY (2005)
An interactional network of genes involved in chitin synthesis in Saccharomyces cerevisiae -: art. no. 8
G Lesage et al.
BMC GENETICS (2005)
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
K Andries et al.
SCIENCE (2005)
Analysis of β-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin
G Lesage et al.
GENETICS (2004)
Global mapping of the yeast genetic interaction network
AHY Tong et al.
SCIENCE (2004)
Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast
G Giaever et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes
PY Lum et al.
CELL (2004)
Exploration of essential gene functions via titratable promoter alleles
S Mnaimneh et al.
CELL (2004)
In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients
WJ Steinbach et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways
AB Parsons et al.
NATURE BIOTECHNOLOGY (2004)
Calcineurin signaling in Saccharomyces cereviside:: how yeast go crazy in response to stress
MS Cyert
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Comprehensive transposon mutant library of Pseudomonas aeruginosa
MA Jacobs et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery
T Roemer et al.
MOLECULAR MICROBIOLOGY (2003)
Why is big Pharma getting out of antibacterial drug discovery?
SJ Projan
CURRENT OPINION IN MICROBIOLOGY (2003)
Experimental determination and system level analysis of essential genes in Escherichia coli MG1655
SY Gerdes et al.
JOURNAL OF BACTERIOLOGY (2003)
Caspofungin: the first in a new class of antifungal agents
NA Kartsonis et al.
DRUG RESISTANCE UPDATES (2003)
Systematic discovery of multicomponent therapeutics
AA Borisy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Essential Bacillus subtilis genes
K Kobayashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Genes required for mycobacterial growth defined by high density mutagenesis
CM Sassetti et al.
MOLECULAR MICROBIOLOGY (2003)
Resistance of human fungal pathogens to antifungal drugs
D Sanglard
CURRENT OPINION IN MICROBIOLOGY (2002)
Functional profiling of the Saccharomyces cerevisiae genome
G Giaever et al.
NATURE (2002)
A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae
BJ Akerley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
A genome-wide strategy for the identification of essential genes in Staphylococcus aureus
RA Forsyth et al.
MOLECULAR MICROBIOLOGY (2002)
Systematic genetic analysis with ordered arrays of yeast deletion mutants
AHY Tong et al.
SCIENCE (2001)
In vitro and in vivo effects of 14α-demethylase (ERG11) depletion in Candida glabrata
H Nakayama et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2001)
Tetracycline-regulatable system to tightly control gene expression in the pathogenic fungus Candida albicans
H Nakayama et al.
INFECTION AND IMMUNITY (2000)
Synergistic antifungal activities of bafilomycin A1, fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans
M Del Poeta et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2000)
Depletion of the squalene synthase (ERG9) gene does not impair growth of Candida glabrata in mice
H Nakayama et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2000)
分享论文
