相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum
Michal Marzec et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers
Komal Jhaveri et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
Evolution and function of diverse Hsp90 homologs and cochaperone proteins
Jill L. Johnson
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
Development of a Grp94 inhibitor
Adam S. Duerfeldt et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Proteomic analysis of plasma membranes isolated from undifferentiated and differentiated HepaRG cells
Izabela Sokolowska et al.
PROTEOME SCIENCE (2012)
Design, synthesis, and evaluation of small molecule Hsp90 probes
Tony Taldone et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab
Shanu Modi et al.
CLINICAL CANCER RESEARCH (2011)
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
Kamalika Moulick et al.
NATURE CHEMICAL BIOLOGY (2011)
GRP94 in ER quality control and stress responses
Davide Eletto et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2010)
Identifying and Characterizing Binding Sites and Assessing Druggability
Thomas A. Halgren
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2009)
Different Poses for Ligand and Chaperone in Inhibitor-Bound Hsp90 and GRP94: Implications for Paralog-Specific Drug Design
Robert M. Immormino et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
The Chaperone Activity of GRP94 Toward Insulin-like Growth Factor II Is Necessary for the Stress Response to Serum Deprivation
Olga Ostrovsky et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models
Eloisi Caldas-Lopes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells
Olga Ostrovsky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The Hsp90 molecular chaperone: an open and shut case for treatment
Laurence H. Pearl et al.
BIOCHEMICAL JOURNAL (2008)
gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A
Xi Na et al.
INFECTION AND IMMUNITY (2008)
The ATPase cycle of the mitochondrial Hsp90 analog trap1
Adriane Leskovar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Discovery and development of purine-scaffold Hsp90 inhibitors
Gabriela Chiosis et al.
EXPERT OPINION ON DRUG DISCOVERY (2008)
GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor Secretion
Sherry Wanderling et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer
Anna Rodina et al.
NATURE CHEMICAL BIOLOGY (2007)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
ER chaperones in mammalian development and human diseases
Min Ni et al.
FEBS LETTERS (2007)
Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages
Yi Yang et al.
IMMUNITY (2007)
Extra precision glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes
Richard A. Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Synthesis of a red-shifted fluorescence polarization probe for Hsp90
Kamalika Moulick et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors
Robert M. Immormino et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex
MMU Ali et al.
NATURE (2006)
Optimal description of a protein structure in terms of multiple groups undergoing TLS motion
J Painter et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2006)
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90
HZ He et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
The HSP90 family of genes in the human genome: Insights into their divergence and evolution
B Chen et al.
GENOMICS (2005)
Structure of unliganded GRP94, the endoplasmic reticulum Hsp90 - Basis for nucleotide-induced conformational change
DE Dollins et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein
D Cabanes et al.
EMBO JOURNAL (2005)
Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90
L Llauger et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
RA Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Glide: A new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening
TA Halgren et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Development of a fluorescence polarization assay for the molecular chaperone Hsp90
J Kim et al.
JOURNAL OF BIOMOLECULAR SCREENING (2004)
Coot:: model-building tools for molecular graphics
P Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms
L Wright et al.
CHEMISTRY & BIOLOGY (2004)
Structure of the N-terminal domain of GRP94 - Basis for ligand specificity and regulation
KL Soldano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The Stress Response: Implications for the Clinical Development of Hsp90 Inhibitors
Luke Whitesell et al.
CURRENT CANCER DRUG TARGETS (2003)
Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase
G Chiosis et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2002)
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2 Neu
WP Xu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
ATPases as drug targets:: Learning from their structure
P Chène
NATURE REVIEWS DRUG DISCOVERY (2002)
EGFR and ErbB2 differentially regulate Raf-1 translocation and activation
LF Zhang et al.
LABORATORY INVESTIGATION (2002)
Cell surface targeting of heat shock protein gp96 induces dendritic cell maturation and antitumor immunity
H Zheng et al.
JOURNAL OF IMMUNOLOGY (2001)
A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells
G Chiosis et al.
CHEMISTRY & BIOLOGY (2001)
Sensitivity of mature ErbB2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90
WP Xu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Untangling the ErbB signalling network
Y Yarden et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)