期刊
NATURE CHEMICAL BIOLOGY
卷 8, 期 11, 页码 926-932出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1087
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资金
- Deutsche Forschungsgemeinschaft [ER 646/1-1]
- US National Institutes of Health [R01GM065155, R01GM095742, P01GM071790, U54GM093342]
Functional assignment of uncharacterized proteins is a challenge in the era of large-scale genome sequencing. Here, we combine in extracto NMR, proteomics and transcriptomics with a newly developed (knock-out) metabolomics platform to determine a potential physiological role for a ribulose-1,5-bisphosphate carboxylase/oxygenase (RubisCO)-like protein from Rhodospirillum rubrum. Our studies unraveled an unexpected link in bacterial central carbon metabolism between S-adenosylmethionine-dependent polyamine metabolism and isoprenoid biosynthesis and also provide an alternative approach to assign enzyme function at the organismic level.
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