期刊
NATURE CHEMICAL BIOLOGY
卷 8, 期 5, 页码 431-433出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.915
关键词
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资金
- US National Science Foundation
- US National Institutes of Health
- Howard Hughes Medical Institute
Here we show that bacterial communication through indole signaling induces persistence, a phenomenon in which a subset of an isogenic bacterial population tolerates antibiotic treatment. We monitor indole-induced persister formation using microfluidics and identify the role of oxidative-stress and phage-shock pathways in this phenomenon. We propose a model in which indole signaling 'inoculates' a bacterial subpopulation against antibiotics by activating stress responses, leading to persister formation.
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