期刊
NATURE CHEMICAL BIOLOGY
卷 8, 期 3, 页码 235-237出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.779
关键词
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资金
- US National Science Foundation [1054964]
- US National Institutes of Health [GM98579, GM65933]
- Direct For Biological Sciences
- Div Of Biological Infrastructure [1054964] Funding Source: National Science Foundation
Determining mechanisms of drug action in human cells remains a major challenge. Here we describe an approach in which multiple-drug-resistant clones are isolated and transcriptome sequencing is used to find mutations in each clone. Further analysis of mutations common to more than one clone can identify a drug's physiological target and indirect resistance mechanisms, as indicated by our proof-of-concept studies of the cytotoxic anticancer drugs BI 2536 and bortezomib.
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