4.8 Article

A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Cell Biology

When simple agonism is not enough: Emerging modalities of GPCR ligands

Nicola J. Smith et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)

Article Multidisciplinary Sciences

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

Soren G. F. Rasmussen et al.

NATURE (2011)

Article Multidisciplinary Sciences

Crystal structure of the β2 adrenergic receptor-Gs protein complex

Soren G. F. Rasmussen et al.

NATURE (2011)

Article Multidisciplinary Sciences

Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1

Louisa Dowal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Biochemistry & Molecular Biology

Therapeutic potential of β-arrestin- and G protein-biased agonists

Erin J. Whalen et al.

TRENDS IN MOLECULAR MEDICINE (2011)

Article Biotechnology & Applied Microbiology

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements

Ralf Schroeder et al.

NATURE BIOTECHNOLOGY (2010)

Review Biotechnology & Applied Microbiology

Teaching old receptors new tricks: biasing seven-transmembrane receptors

Sudarshan Rajagopal et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Biochemistry & Molecular Biology

Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity

Johannes Antony et al.

FASEB JOURNAL (2009)

Article Biochemistry & Molecular Biology

The C-terminal Tail of CRTH2 Is a Key Molecular Determinant That Constrains Gαi and Downstream Signaling Cascade Activation

Ralf Schroeder et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Multidisciplinary Sciences

The structure and function of G-protein-coupled receptors

Daniel M. Rosenbaum et al.

NATURE (2009)

Article Biotechnology & Applied Microbiology

OPINION Cellular assays as portals to seven-transmembrane receptor-based drug discovery

Terry P. Kenakin

NATURE REVIEWS DRUG DISCOVERY (2009)

Review Biochemistry & Molecular Biology

5-Oxo-ETE and the OXE receptor

Gail E. Grant et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2009)

Review Biochemistry & Molecular Biology

G protein βγ subunits:: Central mediators of G protein-coupled receptor signaling

A. V. Smrcka

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Review Pharmacology & Pharmacy

Versatility of GPCR recognition by drugs: from biological implications to therapeutic relevance

Barbara Bosier et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2007)

Review Pharmacology & Pharmacy

Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates

Jillian G. Baker et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2007)

Review Pharmacology & Pharmacy

The evasive nature of drug efficacy:: implications for drug discovery

Segolene Galandrin et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2007)

Article Pharmacology & Pharmacy

PGD2 metabolism in plasma:: Kinetics and relationship with bioactivity on DP1 and CRTH2 receptors

Rufina Schuligoi et al.

BIOCHEMICAL PHARMACOLOGY (2007)

Article Pharmacology & Pharmacy

Functional selectivity and classical concepts of quantitative pharmacology

Jonathan D. Urban et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)

Article Biotechnology & Applied Microbiology

Opinion - How many drug targets are there?

John P. Overington et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Article Biochemistry & Molecular Biology

Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes

Celine Gales et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)

Article Multidisciplinary Sciences

Differential targeting of Gβγ-subunit signaling with small molecules

TM Bonacci et al.

SCIENCE (2006)

Article Biochemical Research Methods

Real-time monitoring of receptor and G-protein interactions in living cells

C Galés et al.

NATURE METHODS (2005)

Article Chemistry, Medicinal

ZINC - A free database of commercially available compounds for virtual screening

JJ Irwin et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2005)

Article Multidisciplinary Sciences

Gi protein activation in intact cells involves subunit rearrangement rather than dissociation

M Bünemann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

M Azzi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Identification of a novel human eicosanoid receptor coupled to Gi/o

T Hosoi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Immunology

The coupling of 5-oxo-eicosanoid receptors to heterotrimeric G proteins

JT O'Flaherty et al.

JOURNAL OF IMMUNOLOGY (2000)