期刊
NATURE CHEMICAL BIOLOGY
卷 8, 期 12, 页码 966-968出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1109
关键词
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资金
- US National Institutes of Health (NIH) [R01GM094263]
- Natural Sciences and Engineering Research Council of Canada
- Simon Fraser University
Visualization of the reaction coordinate undertaken by glycosyltransferases has remained elusive but is critical for understanding this important class of enzyme. Using substrates and substrate mimics, we describe structural snapshots of all species along the kinetic pathway for human O-linked beta-N-acetylglucosamine transferase (O-GlcNAc transferase), an intracellular enzyme that catalyzes installation of a dynamic post-translational modification. The structures reveal key features of the mechanism and show that substrate participation is important during catalysis.
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