期刊
NATURE CHEMICAL BIOLOGY
卷 8, 期 6, 页码 527-535出版社
NATURE RESEARCH
DOI: 10.1038/NCHEMBIO.975
关键词
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资金
- Harvard University Center for the Environment
- US National Science Foundation Synthetic Biology Engineering Research Center
- Radcliffe Institute of Advanced Study
- Wyss Institute for Biologically Inspired Engineering
- Department of Defense Army Research Office
- Department of Energy Advanced Research Projects Agency-Energy
Metabolism is a highly interconnected web of chemical reactions that power life. Though the stoichiometry of metabolism is well understood, the multidimensional aspects of metabolic regulation in time and space remain difficult to define, model and engineer. Complex metabolic conversions can be performed by multiple species working cooperatively and exchanging metabolites via structured networks of organisms and resources. Within cells, metabolism is spatially regulated via sequestration in subcellular compartments and through the assembly of multienzyme complexes. Metabolic engineering and synthetic biology have had success in engineering metabolism in the first and second dimensions, designing linear metabolic pathways and channeling metabolic flux. More recently, engineering of the third dimension has improved output of engineered pathways through isolation and organization of multicell and multienzyme complexes. This review highlights natural and synthetic examples of three-dimensional metabolism both inter- and intracellularly, offering tools and perspectives for biological design.
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