期刊
NATURE CHEMICAL BIOLOGY
卷 7, 期 5, 页码 257-259出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.542
关键词
-
资金
- United States Department of Agriculture Initiative for Future Agriculture and Food Systems
- National Science Foundation
The cyclic peptide sunflower trypsin inhibitor 1 (SFTI-1) blocks trypsin and is a promising drug lead and protein engineering scaffold. We show that SFTI-1 and the newfound SFT-L1 are buried within PawS1 and PawS2, precursors for seed storage protein albumins. Proalbumins are matured by asparaginyl endopeptidase, which we show is required to liberate both ends of SFTI-1 as well as to mature PawS1 albumin. Thus, these peptides emerge from within an albumin precursor by the action of albumin's own processing enzyme.
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