期刊
NATURE CHEMICAL BIOLOGY
卷 7, 期 6, 页码 348-350出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.559
关键词
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资金
- Canada Research Chairs
- Canadian Cystic Fibrosis Foundation
- Canadian Institutes of Health Research [MOP-81330, XNE-8705, FRN-79488]
- European Research Council
Combinations of antibiotics are commonly used in medicine to broaden antimicrobial spectrum and generate synergistic effects. Alternatively, combination of nonantibiotic drugs with antibiotics offers an opportunity to sample a previously untapped expanse of bioactive chemical space. We screened a collection of drugs to identify compounds that augment the activity of the antibiotic minocycline. Unexpected synergistic drug combinations exhibited in vitro and in vivo activity against bacterial pathogens, including multidrug-resistant isolates.
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