期刊
NATURE CHEMICAL BIOLOGY
卷 6, 期 4, 页码 273-275出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.317
关键词
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资金
- Alberta Ingenuity Graduate Scholarship
- Natural Sciences and Engineering Research Council of Canada
- Canada Research Chair in Plant Metabolic Processes Biotechnology
Two previously undetected enzymes involved in morphine biosynthesis and unique among plants to opium poppy have been identified as non-heme dioxygenases, in contrast to the functionally analogous cytochrome P450s found in mammals. We used functional genomics to isolate thebaine 6-O-demethylase (T6ODM) and codeine O-demethylase (CODM), the only known 2-oxoglutarate/Fe(II)-dependent dioxygenases that catalyze O-demethylation. Virus-induced gene silencing of T6ODM and CODM in opium poppy efficiently blocked metabolism at thebaine and codeine, respectively.
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