期刊
NATURE CHEMICAL BIOLOGY
卷 5, 期 4, 页码 236-243出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.147
关键词
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资金
- National Institute of Aging [AG031300]
- National Cancer Institute [CA118498]
- Mattina Proctor Foundation
- Claflin Distinguished Scholar Award
- NATIONAL CANCER INSTITUTE [R01CA115772, R01CA140188, R01CA118498] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [K01AG031300] Funding Source: NIH RePORTER
It has been proposed that inhibitors of an oncogene's effects on multipotent hematopoietic progenitor cell differentiation may change the properties of the leukemic stem cells and complement the clinical use of cytotoxic drugs. Using zebrafish, we developed a robust in vivo hematopoietic differentiation assay that reflects the activity of the oncogene AML1-ETO. Screening for modifiers of AML1-ETO-mediated hematopoietic dysregulation uncovered unexpected roles of COX-2- and beta-catenin-dependent pathways in AML1-ETO function. This approach may open doors for developing therapeutics targeting oncogene function within leukemic stem cells.
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